V.I. Tseluiko, L.M. Yakovleva, T.M. Bondar Role of endothelial NO-synthase T-786C gene polymorphism for nitric oxide metabolism violations and development of atherosclerosis.

The results of clinical studies regarding possible relation of endothelial NO-synthase gene polymorphism to risk of cardiovascular disease and atherosclerosis, in particular, as well as molecular mechanisms of genetic
influence of NO-synthase on NO availability are discussed. The results of own studies of promoter polymorphism T-786S of endothelial NO-synthase gene prevalence in patients with coronary heart disease in the Ukrainian
population are presented.

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