A.A. Al Salim, M.A. Stanislavchuk, N.V. Zaichko Relationship of LEPR Q223R gene polymorphism to cardiometabolic risk factors in postmyocardial infarction men with type 2 diabetes mellitus

The aim – to determine the relationship of leptin receptors LEPR Q223R gene polymorphism to cardiometabolic risk factors in postinfarction men with type 2 diabetes mellitus (DM).

Material and methods. The study involved 147 men with stable coronary heart disease after myocardial infarction, mean age 53.70±6.97 years. In 64 (43.5 %) patients coronary heart disease was combined with type 2 DM. LEPR Q223R gene polymorphism was determined by PCR mode real-time. We evaluated the prevalence of traditional markers of dyslipidemia, inflammatory syndrome, insulin resistance, depending on LEPR Q223R genotype.

Results. In patients with coronary heart disease and type 2 DM the prevalence of LEPR Q223R gene polymorphism was higher than in CHD patients without DM (OR 1.58; 95 % CI 0.99–2.53). LEPR Q223R gene polymorphism was associated with visceral obesity and proatherogenic pattern, especially in patients with CHD combined with type 2 DM. In the RR genotype carriers we registered more often hypertension (OR 2.81; 95 % CI 1.03–7.18), markers of visceral obesity (OR 5.37; 95 % CI 2.56–11.3), insulin resistance, dyslipidemia (hypertriglyceridemia, low HDL cholesterol) and high levels of hsCRP than in the QQ and QR genotype carriers.

Conclusions. In patients with CHD and type 2 DM LEPR Q223R gene polymorphism was associated with visceral obesity, insulin resistance and metabolic proatherogenic pattern.

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