It was established that increase of blood pressure in rats with spontaneous hypertension occurs as a sign of a complex reaction including components such as proatherogenic dyslipidemia, hyperglycemia, proinflammatory
status which are peculiar to insulin resistance syndrome. The metabolic disturbances in these conditions were independent of hypertension and could be induced in its absence. One of the most important reasons and
common pathogenetic mechanisms of combined development of arterial hypertension, systemic metabolic disturbances and systemic inflammation was activation of the renin-angiotensin system, and its blockade eliminated the development of both hypertension and accompanying metabolic disturbances.