This paper presents analysis and results of multicenter studies of efficacy of statins in patients with ischemic heart disease, as well as in patients after coronary stenting. It shows the data on the effectiveness of statins in patients with congestive heart failure of ischemic origin, and for the prevention of atrial fibrillation. It summarizes the data on the tolerability of statins and the prevalence of side effects. Also it shows the results of studies on the compatibility of statins with other drugs used in cardiology practice. According to the latest recommendations of the European Society of Cardiology, it presents data on the target levels of serum total cholesterol, lowdensity lipoprotein, very-low-density lipoprotein and triglycerides.