N.M. Seredyuk, Abu Oudeh Faraj Subclinical injuries: rigidity of aorta, high pulse rate and other risk factors in the evaluation of the treatment efficacy in patients with angina and arterial hypertension
Hundred and fifty eight patients were monitored, among them 93 diagnosed with stable angina (SA), and 65 with unstable angina (UA) and AH of II stage. Among the subclinical injuries of organs-targets the principal place belongs to pulse arterial pressure and rigidity of aorta. The index of rigidity of aorta (normal (1.05±0.07) mm/ml) significantly increases with SA ((1.90±0.05) mm/ml) and especially UA ((2.08±0.07) mm/ml) (Р<0,001), which is the evidence of high cardiovascular risk. The index of rigidity of aorta correlates well with other markers of subclinical injuries: pulse wave velocity, intima-media thickness and endothelinemia. Inhibitor of If-channels ivabradin not only reduces the frequency of heart rate, but also reduces the pulse arterial pressure, rigidity of aorta, pulse wave velocity.