Yе.P. Svyshchenko, L.A. Mishchenko, on behalf of the trial «Age of vessels» participants. New concept evaluation of cardiovascular risk by Framingham criteria – determination of the age of vessels. The first experience in Ukrainian population of patients with arterial hypertension

The aim – to presented the results of the trial of cardiovascular risk stratification in hypertensive patients using Framingham criteria of evaluation of the vessels age.

Material and methods. 987 patients with uncontrolled arterial hypertension were included in this epidemiologic multicenter study. Determination of the calculated vessels age was done based on estimation of blood pressure (BP) level, presence of diabetes mellitus, smoking status, blood levels of total cholesterol and high density lipoprotein cholesterol.

Results. Discrepancy between passport age of patient and age of vessels, calculated by the Framingham criteria, was detected in the Ukrainian population of patients with hypertension. This is due to the increase of blood pressure and high prevalence of risk factors, such as dyslipidemia (76 %), smoking (29.9 %) and diabetes mellitus (24 %). It was established that these risk factors exert a significant influence on younger people compared to the elderly. The presence of dyslipidemia in patients with hypertension increases calculated age of the vessels by 6 years, diabetes – by 5 years, compared to patients with normal lipid and carbohydrate metabolism. Smoking adds further 3 years, and increased blood pressure of 140/90–159/99 to 180/110 mmHg or greater increases the average age of the vessel by 8 years.

Conclusions. Our findings give evidence of unfavorable impact of cardiovascular risk factors (especially their combinations) upon premature aging of the vessels.

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