O.S. Sychov, A.O. Borodai Predictors of quality of life in patients with non-valvular atrial fibrillation-flutter

The aim – to identify factors that might predict reduced quality of life scores in patients with non-valvular atrial fibrillation-flutter (AF-AFl).

Material and methods. In prospective cross-sectional study we evaluated 328 patients with non-valvular AF-AFl, mean age 61.7±9.96 years, among them 126 (38.4 %) females. The quality of life was assessed by means of specific instruments AF-QоL and AFEQT.

Results. The lowest overall score by AFEQT (48.1±19.7) as well as by AF-Qol (38.3±17.6) was registered in patients with paroxysmal AF-AFl and the highest overall score – patients with persistent AF-AFl after cardioversion (68.7±20.8 and 52.5±19.1, correspondingly). In multivariate regression model independent predictors of global AF-Qol were class NYHA (β=0.22, Р<0.001), HADS anxiety (β=–0.21, Р<0.001), HADS depression (β=–0.20, Р<0.001), paroxysmal form of arrhythmia (β=–0.16, Р=0.001), CHA2DS2VASc score (β=–0.6, Р=0.002). Independent predictors of the overall AFEQT score were class NYHA (β=–0.38, Р<0.001), HADS anxiety (β=–0.25, Р<0.001), female gender (β=–0.22, Р<0.001) and paroxysmal form of arrhythmia (β=–0.14, Р=0.001). Conclusions. Heart failure class NYHA, symptoms of anxiety, depression, female gender and paroxysmal form of arrhythmia were associated with significantly reduced quality of life in patients with non-valvular atrial fibrillation-flutter.

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