O.S. Sychov, A.O. Borodai, O.M. Romanova, S.V. Lysogub, O.V. Sribna, O.V. Levchuk, E.S. Borodai. Gender issues of quality of life and emotional state in patients with non-valvular atrial fibrillation and flutter.

The aim – to evaluate gender issues of quality of life and emotional state in patients with non-valvular atrial fibrillation and flutter (AF-AFl).

Material and methods. We examined 322 patients with non-valvular atrial fibrillation and flutter, among them 223 (69.3 %) males and 99 (30.7 %) females. Clinical examination, laboratory tests, transthoracic echocardiography were performed in all patients. Quality of life was assessed by HeartQol, anxiety and depression were examined by HADS, additional questionnaires were applied for assessment of adherence to therapy.

Results. There were no significant differences of left ventricle ejection fraction between females (54.9±10.1 % and males 53.1±11.0 %, Р=0.19). In the meantime, there were significant differences in physical (1.8±0.9 vs 1.2±0.8, Р<0.0001), and emotional dimensions (2.3±0.9 vs 1.7±0.9, Р<0.0001) of quality of life for males and females, correspondingly. Also, females had higher level of anxiety (7.8±3.2 vs 5.4±2.7, Р<0.0001) and depression (5.6±3.6 vs 4.2±3.0, Р=0.001). Вesides, HADS anxiety ≥ 11 was revealed in 24.4 % females vs 3.1 % males, Р<0.0001, and HADS depression ≥ 11 – in 12.2 % females vs 3.6 % males, Р=0.005. Females had significantly more symptomatic course of arrhythmia with EHRA IV (19.3 % vs 5.6 % among males, Р=0.0002). In multivariate logistic regression model female gender was independently associated with low physical and emotional components of HeartQol < 1.8 (Р=0.01 for both) and with EHRA IV (Р=0.008). Conclusions. Females with AF-AFl had more symptomatic course of arrhythmia, lower quality of life and higher prevalence of anxiety and depression.

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