O.V. Sinyachenko, G.S. Taktashov, M.V. Iermolaeva. Cardioprotective and cardiotoxic trace elements in chronic rheumatic heart disease

The aim – to assess blood content of trace elements (Cd, Co, Cu, Pb, Zn) in patients depending on clinical course of chronic rheumatic heart disease (CRHD), to establish prognostic significance of microelementosis and its role in pathogenesis of cardiorespiratory changes.

Material and methods. 105 patients at the age from 15 to 60 years were included, among them 28 % men and 72 % women. The serum content of trace elements was studied by atomic absorption spectrometry.

Results. In patients with CRHD blood Cd was increased by 9 %, Cu reduced by 10 %, Zn – by 5 % and Pb – by 2.2 times. These changes depend on the character of heart defects, surgery performed at the previous stages, cardiac arrhythmias, size of heart cavities, degree of valvular fibrosis, functional class of heart failure (FCHF). Trace elements involved in the pathogenesis of CRHD determine the pressure in the pulmonary artery (Co) and pulmonary vascular resistance (Cu, Pb), FKHF (Cu, Zn, Cd, Co), and disorders of moisture production and lung diffusion capacity.

Conclusions. CRHD is accompanied by marked blood microelementosis of cardiotoxic (Cd, Pb) and cardioprotective trace elements (Cu, Zn), which is closely related to the course, pathogenesis of heart and respiratory changes.

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