N.V. Kostyushova The diagnostic significance of sulfhydryl and disulfide groups in patients with acute coronary syndrome.

The aim of the research was to study the functional state of protein and non-protein .SH and .S.S. groups and to prove their diagnostic value in patients with acute coronary syndrome (ACS). One hundred and two patients (86 men and 16 women, age 28.65 years) with ACS have been examined. Forty nine patients had unstable angina pectoris {AP), 27 . non-Q wave myocardial infarction (non-Q MI) and 26 . Q-wave myocardial infarction
(Q-MI). The tests have been performed within 6 hours after the onset of angina attack. The control group consisted of healthy volunteers . 100 persons (92 men and 8 women, age 20.65 years). Contents of .SH and
.S.S. groups were estimated by amperometric titration technique. According to their ratio, SH/SS factors have been calculated. It has been found that in case of the exacerbation of the coronary heart disease clinical, ECG and laboratory signs were associated with changes of correlation between quantity of .SH and .S.S. groups in proteins and low-molecular thiols. This imbalance is increasing along with severity of the clinical course of the disease: AP non-Q MI – Q-MI. The causes, mechanism of their disorder and their role in pathogenesis of unstable angina pectoris and myocardial infarction have been discussed. It has been proved that .SH and .S.S
group indicators and SH/SS factors may be used in cardiology as additional laboratory tests for diagnosis of angina pectoris, non-Q MI and Q-MI.

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