O.Ye. Yadlovskyi, T.A. Bukhtiarova.The effect of a new non-opioid analgesic pirodazol on hemodynamics of rats.

The effect of a new non-opioid analgetic drug pirodazol upon hemodynamic parameters was studied as aspect of safety pharmacology. The study was conducted on white rats. Pirodazol was administered intramuscularly in doses of 1/20 LD50, 1/4 LD50, 1/2 LD50 (1,1; 5,5 and 11 mg kg respectively). Dose-related specific hemodynamic changes were elicited starting from the 30th min after single pyrodazol injection administration. Maximal hypotensive effect (up to -51.66 %) was achieved at the dose of 11 mg/kg. The hypotensive effect was accompanied by compensatory tachycardia, decreased cardiac output (up to –62.8 %) and systemic vascular resistance (up to –30.6 %). At a dose of 1.1 mg/kg hemodynamic changes were not significant, apart from changes of total peripheral vascular resistance at 30 and 60 min after administration.

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