Clinical efficiency and safety of 12-weeks treatment with S-amlodipine, as well its influence on central, intracardial hemodynamics, daily dynamics of blood pressure (BP) and ECG, structural and functional state of the heart were studied in elderly hypertensives. Target level of BP was achieved in 67 % patients under daily S-amlodipine dosage 5.0–7.5 mg. The positive influence of S-amlodipine on BP circadian rhythm, left ventricular hypertrophy regression, improvement of diastolic function and decrease of cardiac arrhythmias were shown. Treatment with S-amlodipine appeared to be safe in elderly hypertensives: no cases of severe of adverse events and adverse drug reactions were reported. Facial flushing and headache (7 %) were transitory and didn’t demand medicine withdrawal, while the case of the peripheral edema was registered under dosage of S-amlodipine 7.5 mg.