O.I. Mitchenko, V.Yu. Romanov, K.O. Yanovska The endocrine activity of adipose tissue and surrogate markers of atherosclerosis in patients with metabolic syndrome

The aim of our study was to determine the link between the endocrine activity of adipose tissue, intima – media thickness (IMT), endothelium-dependent vasodilatation depending on body mass index and insulin resistance. We examined 174 patients with metabolic syndrome (women – 88, men – 86), which were divided into the clinical groups according to body mass index and HOMA. We determined body mass index, glucose, insulin,
HOMA, leptin, adiponectin, the ratio leptin/adiponectin, blood lipids, IMT in the common carotid artery, endothelium-dependent vasodilatation. In women we observed significant relation between progression of insulin resistance, increase of IMT and deterioration of endothelial function; in male patients the tendency to increase of IMT and reduction of endothelium-dependent vasodilatation was shown. It has been proved that irrespective of gender increase of body mass thickness was associated with increase of intima – media complex of the common carotid artery and decrease of endothelium-dependent vasodilatation index. Progression of insulin resistance was associated with atherogenesis in the common carotid artery.

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