V.Y. Tseluyko, S. Daghar. Galectin-3 level and Holter ECG monitoring results in patients with hypertrophic cardiomyopathy

The aim – to investigate the relationship between galectin-3 level and heart rhythm disorders in patients with hypertrophic cardiomyopathy (HCM).
Material and methods. We examined 90 patients with HCM, mean age 50.2±16.2 years, 47 males, 43 females. 84 patients had asymmetric hypertrophy, 6 – symmetric hypertrophy. In 64.4 % patients hypertrophy was significant (over 20 mm). 26 patients had obstruction. Physical examination, Holter ECG, cardiac ultrasound and galectin-3 level detection were performed in all patients.
Results. Holter ECG revealed high frequency of heart rhythm disorders. Ventricular extrasystoles (VEs) were present in 70 (80.0 %) of patients. The number of VE varied widely among patients with the highest number of 6291. 27 (30.0 %) patients had paired VEs, 17 (18.9 %) had runs of ventricular tachycardia. 22 (24.4 %) of patients had paroxysmal supraventricular tachycardia. We found correlation between galectin-3 level and Holter ECG monitoring results (number of paired supraventricular extrsystoles and episodes of ST depression, episodes of QT prolongation).
Conclusion. In patients with HCM, high galectin-3 level is associated with heart rhythm disorders, episodes of ST depression, QT prolongation at Holter ECG monitoring.

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