The pilot registry of acute coronary syndromes with ST segment elevation STIMUL, including 1103 pts, is the first registry research in Ukraine with two- years follow-up. Our study aimed to examine the characteristics and longterm prognosis of patients with myocardial infarction with ST segment elevation and to compare their adherence to the current guidelines. After 24 month a prospective survey data included 278 pts, which was elucidated by telephone contacts. 171 pts died between discharge and 24 month follow-up, 61 (21.94%) sustained a new non-fatal myocardial infarction, and 98 pts (35.25%) underwent myocardial revascularization procedures. Compared to survivors, patients who died or had myocardial infarction were older, more often were females, had signs of acute heart failure and high terms of time delay from symptom onset to arrival at the emergency department. Important findings of the study were relatively low use of recommended treatment guidelines and high rate of cessation of prescribed at discharge medications. Non-adherence to medical treatments leads to more frequent development of recurrent myocardial infarction and death.