The aim – to study the influence of the combined drug of the gluconic acid magnesium and potassium salts on the efficiency of cardioversion in patients with atrial fibrillation (AF) paroxysm, as well as its impact on the atrial electrical instability in patients with sinus rhythm.
Material and methods. One hundred and thirty eight patients (36 women and 102 men) with AF who underwent sinus rhythm restoration were divided into two groups: the 1st – 69 patients that received load dosage of amiodarone, the 2nd – 69 patients that additionally received combined drug of the gluconic acid two capsules three times a day for 20 minutes before meals.
Results. Compared to monotherapy, addition of the metabolic agent reduced the need in electrical cardioversion (42 % vs. 58 %) and the period of the sinus rhythm restoration (6.0±1.1 versus 9.0±1.3 days; Р<0.05 ). The combined therapy reduced the number of isolated supraventricular extrasystoles and couplets during Holter ECG monitoring, compared to monotherapy. Metabolic agent addition was associated with significant increase of exercise tolerance and reduced number of patients with higher class of angina.