The aim – to compare influence of carvedilol and atenolol on diurnal blood pressure monitoring parameters, endothelial vasodilating function and lipid exchange in patients with arterial hypertension (AH).
Materials and methods. 65 patients with arterial hypertension, median age 55 years, were distributed into 2 groups: 41 patients received carvedilol and 24 – atenolol. Before and after 12 weeks of the treatment we performed the following tests: total cholesterol and triglycerides, 24-hour blood pressure monitoring, endothelium dependent vasodilatation (EDVD).
Results. The comparable effect of both medications on parameters of blood pressure monitoring was found. In contrast to atenolol, carvedilol significantly improved endothelial-dependent vasodilation of brachial artery (Р=0.006). The significant reduction of body mass index (Р=0.001), levels of total cholesterol (Р<0.001) and triglycerides (Р=0.042) were revealed under treatment with carvedilol; at the same time, treatment with atenolol was not associated with significant changes of the mentioned parameters. Conclusions. The treatment of patients with AH with carvedilol and atenolol is associated with statistically significant reduction of the indices of daily blood pressure monitoring. Carvedilol significantly improved EDVD in patients with AH, whereas the treatment with atenolol was not associated with positive dynamic of endothelium dependent vasodilatation. The treatment with carvedilol for 12 weeks was also associated with statistically significant reduction of body mass index, the levels of total cholesterol and triglycerides.