О.M. Lomakovsky Influence of statins on immune inflammation, lipids spectrum of blood, oxidation of lipids and proteins in patients with chronic ischemic heart disease

To determine changes of lipid exchange, oxidation of lipids, proteins and immune inflammation under treatment with statins we studied 54 patients with chronic ischemic heart disease (stable angina, II–IV functional classes). Average age of patients was 57 (52–65) years. Patients received two-months treatment with atorvastatin (20 mg daily) (n=22), lovastatin (40 mg daily) (n=12), simvastatin (40 mg daily) (n=20). Immunological and biochemical research was performed on peripheral blood. Statins influenced specific and heterospecific links of immunity in patients with chronic IHD. Influence of statins on humoral (CRP, TNF-α, IL-6, IL-8, IL-10) and cellular (Mc, Tkh, Ts, Tkh/Ts) factors of immune inflammation depended on the initial levels of factors. The more initial level deviated from control, the more identical doses of statins improved it. The inflammatory effect of statins didn’t depend on the decrease of total cholesterol. Decrease of peroxid lipid modification under treatment with statins diminished immune inflammation.

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