Contemporary data regarding efficiency and safety of beta-blockers in arterial hypertension treatment are reviewed in the article. Influence of beta-blockers on cardiovascular events, central blood pressure and arterial stiffness, glucose and lipid metabolism, target organ damage and quality of life in patients with arterial hypertension is analyzed. The rate of adverse events of beta-blockers is not high in clinical trials and is exaggerated by general practitioners. In patients with arterial hypertension having indications beta-blocker treatment is much more useful than no treatment, including patients with diabetes mellitus, metabolic syndrome, chronic obstructive pulmonary diseases and in the elderly. If there is a high risk of adverse reactions the beta-blockers with vasodilation are more preferable.