L.V. Zhuravlyova, N.A. Lopina. Fractalkine level and its importance in forecasting presence and severity of coronary atherosclerosis

The aim – to assess the fractalkine levels in patients with coronary artery disease (CAD), depending on the presence type 2 diabetes mellitus (T2DM), the nature of coronary artery lesions, and its value in predicting the presence and severity of coronary atherosclerotic lesions.
Material and methods. 131 patients with CAD (89 men, 42 women), mean age of 59.60±9.11 years were examined. Depending on the presence of T2DM patients with CAD were divided into 2 groups: 1st group (n=70) – patients with concomitant T2DM, 2nd group (n=61) – patients with CAD without T2DM. All patients were performed coronary angiography to verify the diagnosis of coronary artery disease. Also were assessed the levels of fractalkine.
Results. The study demonstrated that patients with CAD both with concomitant T2DM and without had significantly increased levels of fractalkine compared with the control group (Р<0.05). In patients with diffuse coronary artery disease with concomitant T2DM and without T2DM mellitus fractalkine levels were significantly higher than in patients without diffuse coronary artery lesions (Р<0.05). In the study, the predictive value for the presence of coronary atherosclerosis was set for the value of fractalkine more than 466 pg/ml, the sensitivity and specificity of high and up 85.5 and 95.5 %, respectively, the area under the ROC curve (AUC) – 0.909±0.024 (95 % confidence interval (СІ) 0.852–0.950; Р<0.0001). Prognostic significance for the presence of hemodynamically significant stenosis of the coronary arteries is set for the value of fractalkine more than 468 pg/ml, the sensitivity and specificity of 88.8 % and amount to 56.6 %, respectively, the area under the ROC curve (AUC) – 0.742±0.043 (95 % CI 0.665–0.810; Р<0.0001). Prognostic significance determination fractalkine level for predicting the presence of diffuse coronary artery disease is set for the value of fractalkine more than 596 pg/ml, the sensitivity and specificity of 56 % and account for 96.3 %, respectively, the area under the ROC curve (AUC) – 0.802±0.039 (95 % CI 0.724–0.867; Р<0.0001). Conclusions. Determination of fractalkine level is important in predicting the presence of atherosclerotic lesions of the coronary vessels and the presence of hemodynamically significant coronary artery stenosis, diffuse coronary lesions.

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