I.O. Zhyvylo, G.D. Radchenko, Ye.Yu. Titov, Yu.M. Sirenko Structural and functional status of the systemic circulation arteries in patients with idiopathic pulmonary arterial hypertension with different functional abilities and endpoints

The aim – to study the elastic properties of the systemic circulation arteries in patients with idiopathic pulmonary arterial hypertension (IPAH) with different functional abilities and endpoints.

Мaterial and methods. 152 patients were examined: 45 of them were with IPAH, 40 patients with pulmonary arterial hypertension associated with congenital heart disease, 32 patients with arterial hypertension (AH) and 35 healthy controls. Pulse wave velocity was measured in the arteries of muscular and elastic types, also we measured cardio-ankle vascular index (CAVI).

Results. Patients with reduced (< 330 m) functional abilities (FA) compared with patients with preserved (> 330 m) FA, have significantly higher arterial stiffness: the level of right CAVI was 8.18±0.27 vs 7.02±0.23 (Р<0.005); the level of left – 8.43±0.30 vs 7.07±0.21 (Р<0.005). Comparing groups of patients with reduced FA and with AH, CAVI measurements were higher among patients with IPAH (right side 8.18±0.27 vs 7.53±0.21, Р<0.08, left side 8.43±0.30 vs 7.39±0.20, Р<0.006). The CAVI of patients who died during the observation period was significantly higher compared to the results of surviving patients: 8.60±0.42 vs 7.01±0.20 (Р<0.001) and 8.53±0.46 vs 7.03±0.17 (Р<0.001), accordingly. Conclusions. Consequently, in addition to all known risk factors for complication and 1 year mortality among patients with IPAH, it may be possible to use CAVI as an indicator of arterial lesions of the systemic circulation.

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