Several cases of the successful catheter radiofrequency ablation (RFA) of atrial fibrillation in patients aged 40–54 years with severe heart failure and left ventricle systolic dysfunction due to long-term arrhythmia are presented. Procedures were performed due to low efficacy of the drug treatment. Follow-up duration was 1 to 3 years. Left ventricle systolic function restoration after RFA was observed. All patients stopped prophylactic antiarrhythmic therapy and most of them needed no medication treatment afterwards. All patients returned to fully socially active life. Sinus rhythm preservation tactics is more preferable and must take priority, especially in younger patients. RFA is one of the most wide-spread catheter procedures with proven efficacy, being enough patient-safe. It significantly improves quality of life, and today it becomes the most wide-spread of radical arrhythmia treatment. Stable sinus rhythm preservation is more constant in younger patients with less advanced myocardium structure changes and without advanced concomitant pathology.