O.I. Mitchenko, V.Yu. Romanov, K.O. Yanovska, M.M. Gelmedova, L.V. Yakushko Adipokins and their ratios in patients with metabolic syndrome

The aim of this work was to determine the relationship between plasma levels of adipocytokins, body mass index (BMI), insulin resistance and lipid profile. We examined 174 patients with metabolic syndrome (women – 88,
men – 86) who were divided into clinical groups depending on body mass index and HOMA-index. The following parameters were studied: BMI, glucose, insulin, HOMA-index, leptin, adiponektin, the ratio leptin/adiponektin
(L/A), plasma lipid levels. Regardless of gender, patients with metabolic syndrome demonstrated direct relation between BMI and plasma level of leptin, in contrast to lack of clear relation between BMI and plasma adiponektin. Direct relation between BMI and L/A ratio was revealed, more expressed in men than in women; HOMA-index in men and women was directly related to L/A ratio and negatively – to the level of adiponektin in patients with metabolic syndrome. L/A ratio was directly related to pro-atherogenic lipid spectrum parameters (triglycerides, very low density lipoproteins) and negatively – to high density lipoproteins.

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