A lot of convincing evidence has been accumulated to date showing further progression of atherosclerotic process even when optimal levels of total serum cholesterol have been reached in some patients. This suggests
that the process of atherogenesis is not only determined and depends on hypercholesterolemia. It has been shown that low levels of high density lipoproteins (HDL) and increased levels of triglycerides are also associated
with increased risk of cardiovascular complications. According to the recommendations for primary and secondary prevention of atherosclerosis, aspects of efficiency, compatibility, safety and tolerability of statins,
fibrates and omega-3 polyunsaturated fatty acids are reviewed.