T.A. Mangilyova Heart rate variability during glucose tolerance test in patients with arterial hypertension.

Heart rate variability, heart rate, arterial hypertension, glucose tolerance test were examined in 66 patients with grade 1 arterial hypertension (AH). Control group consisted of 35 patients with optimal or normal blood pressure. Spectral analyses of heart rate variability (HRV), blood glucose concentration and insulin level were checked under fasting and postprandial (1 and 2 hour after taking glucose 75 g) states. Fasting HRV indices (HF, LF and TP) in patients with AH were lower (p<0.05) than in control group. In 2 hours after glucose loading mean values of LF and TP became equal in hypertensive and non-hypertensive persons due to lowering of HF, LF and TP in the control group. Fasting heart rate (HR) was higher in patients with AH (p<0.05). Postprandial (2 hours after meal) differences of HR were not observed. There was moderate negative correlation between HRV indices (mainly HF) and fasting and postprandial HR in both groups. They were more significant in hypertensive patients. Sex and obesity didn’t influence HRV indices. Fasting (p<0.01) and postprandial (p<0.01 1 hour after meal, p<0.05 2 hours after meal) insulin levels were higher in patients with grade 1 AH than in control group, whereas glucose level was greater in main group only in one hour after meal. Thereby, hypertensive patients were characterized by low fasting HRV indices with absence of it postprandial dynamics. HR augmentation leads to HRV lowering, whereas sex and obesity don’t provide such effect. Patients with grade 1 AH show stable hyperinsulinemia and transient hyperglycemia.

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