Morphofunctional reorganization of myocardium in chronic ischemic heart disease were studied based on clinical (postmortem examination and intraoperative tissue samplings) and experimental data (modeling of acute and recurrent coronary insufficiency with vasopressin). General histological, histochemical tests, polarization and electron microscopy were used. It was determined that disease process in myocardium induced and maintained by circulatory hypoxia, implemented with active participation of intramural (sympathetic) innervation involving all cellular elements of fabric district producing wide range of biologically active neurohumoral and immunological factors. They provide interaction potentiating effect on cells secreting. Integral result of these processes was a progressive myocardium interstitial fibrotization and reducing its contractile function, which determine the morphological and clinical patterns of ischemic cardiomyopathy.