The aim of investigation was to study the recovery of tolerance to physical load depending on metabolic disturbances. 105 patients with myocardial infarction were investigated in the acute period, in 3 and 6 months.
All patients were divided into two groups: 1st group (50 patients) received basic therapy and enalapril, the 2nd group (55 patients) in addition to basic therapy received perindopril. All patients carried out bicycle exercise test and complex biochemical investigation which included indices of activity of systemic inflammatory process, intensity of oxidative stress, plasma atherogenic potential, immune response. It was established that low exercise tolerance at 1st investigation was accompanied with dramatic disturbances of lipid and carbohydrate metabolism, atherogenic changes of lipid profile, increasing of inflammatory response and development of oxidant stress. During 6 months of therapy positive dynamics in biochemical indices was observed with parallel improvement of physical loading. More significant and quicker changes were established in patients of 2nd
group who received perindopril.