V.M. Kovalenko, L.S. Mkhitarian, N.M. Orlova, O.G. Nesukai, I.N. Yevstratova, N.M. Vasylynchuk, S.V. CherniukOxidative stress development features and expressiveness of its basic components in coronarogenic and noncoronarogenic heart disease.

The work is devoted to the study of oxidative stress features and comparison of its characteristics in coronarogenic and noncoronarogenic heart disease. The object of the study was blood serum of patients with
ischemic heart disease (IHD), patients with dilated cardiomyopathy (DCMP) and chronic myocarditis (CM). Oxidative stress development and expressiveness was analyzed by activity of protein and lipid free radical
oxidation, as well as change of activity of antioxidant enzymes. The studies that were carried out revealed accompanying oxidative stress development in patients with coronarogenic and noncoronarogenic heart
disease. Precise and moderately accurate signs of oxidative stress were observed in 75 % patients with IHD and DCMP and in 50 % patients with CM. Signs of oxidative stress were most significant in coronarogenic heart
disease. The established activation of free radical oxidation should be regarded as an important mechanism of progressive pathological processes. This phenomen may be considered for patients treatment.

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