The study of quality of life in patients with arterial hypertension participating in 6-month observational study, and its changes under antihypertensive treatment was performed. We included 1055 patients with different stages of arterial hypertension observed by general practitioners. SF-36 test was performed in all patients baseline and at the end of observation. Comparing to the healthy subjects, included patients had significant impairment of all patterns of quality of life, especially role-physical and role-emotional patterns. Physical component summary was significantly decreased, but not mental component summary, compared to the healthy population. Probability of high mental component summary decreased by 32% at systolic blood pressure level > 160 mm Hg, by 23% at concomitant ischemic heart disease, by 44% – at renal diseases, by 41% at high level of total cholesterol. It increased by 37% at high physical activity and by 30% at high baseline compliance. Antihypertensive treatment improved majority parameters of quality of life, except body pain and vitality. Yet, at the end of the study the quality of life patterns did not achieve the level of healthy population.