G.D. Radchenko, T.G. Slashcheva, Yu.M. Sirenko, L.O. Mushtenko. Factors influencing blood pressure control in hypertensive patients depending on age.

The aim – to compare blood pressure (BP) control in Ukrainian population of hypertensive patients and define factors associated with lack of BP control during 3-month antihypertensive therapy depending on age.

Material and methods. 6758 patients with BP > 140/90 mmHg were included into 3-months multicenter (62 towns and 531 primary care physicians) open trial. All patients were divided into two groups: 1st – 4328 patients, age < 65 years; 2nd – 2430 patients, age > 65 years. Primary care physicians prescribed drugs according to their own discretion. During four visits office BP measurements, ECG, patient’s compliance and cardiovascular risk evaluations by standard tests, using original questionnaire, were performed. Multifactor regression analysis was used for evaluation of antihypertensive treatment failure predictors.

Results. In patients older than 65 years arterial hypertension was associated with more rate of complications (heart failure, stroke, myocardial infarction, renal damage) and concomitant diseases (diabetes mellitus, coronary heart disease) and risk factors (obesity, dyslipidemia, high systolic blood pressure). Younger patients more frequently had bad habits (smoke, alcohol and salt abuse), but they frequently had additional physical activity and more intake of fresh fruits and vegetables. Baseline, only 27.2 % patients of the 1st group and 24.8 % of the 2nd group (P<0.05) had high compliance. During the treatment, the rate of patients with low compliance decreased and rate of high or moderate compliance increased in both groups. At the end of follow-up patients of the 1st group had significantly less mean blood pressure level, than patients of the 2nd group. The target blood pressure was achieved in 63.7 % of younger patients and in 54 % of older patients (P<0.001). Conclusions. Older patients had worse blood pressure control than younger patients during the 3-month treatment. Despite common predictors of poor blood pressure control in both groups, some differences were revealed, which should be taken into account during treatment of different age patients.

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