O.I. Mitchenko, V.Yu. Romanov, K.O. Yanovska The correction of endothelial dysfunction and thickness of intima – media in patients with essential hypertension and metabolic syndrome.

The aim of the research was to study the features of endothelial function and intima – media thickness (IMT) in patients with hypertension and metabolic syndrome (MS) under use of fixed combination of amlodipine and
atorvastatin versus using combination of lisinopril and atorvastatin. We included 50 patients with hypertension and MS, which were divided into four clinical groups: 1st group (n=14) – men, who used fixed combination
(average age 54.5±2.9 years); 2nd group (n=16) – women, who used fixed combination (average age 60.0±3.9 years); 3rd group (n=10) – men, who used combination of lisinopril and atorvastatin (average age 56.1±2.4
years) and the 4th group (n=10) – women, who used combination of lisinopril and atorvastatin (average ages 59.2±2.6 years). In all patient we determined: anthropometric data (growth, weight, body mass index), blood
lipid profiles, measuring of IMT of total carotid artery, endothelial function of brachial artery. It was found that antihypertensive and lipid-lowering effects in both groups were comparable. But we observed normalization of endothelial vasodilatation in 100 % patients under fixed combination amlodipine and atorvastatin versus 85 % under treatment with lisinopril and atorvastatin, as well as more significant impact on intima – media thickness of total carotid artery under fixed combination.

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