In order to study the predicted survival rate during the 1, 2, 3 and 5 years depending on the total score indices of the Physical Health Component Living Quality Questionnaire SF-36, 554 patients with chronic heart failure of III functional class after NYHA were evaluated. During the first research stage by means of cluster analysis (k-average method), sub-groups of patients were selected, which were non-overlapping regarding values of the Physical Health Component Questionnaire SF-36 indicator and at the same time were definitely dissimilar to cumulative survival during the 1, 2, 3 and 5 years. The indicated sub-groups were homogeneous regarding value of left ventricular ejection fraction, number of patients receiving angiotensin-converting enzyme inhibitors, beta-adrenoceptor blockers and gender distribution. During the second stage the relative risk was calculated by Cox regression of fatal end for the patient cluster with range of values of overall life quality index associated with reliable inferior survival during each of the given investigation period. The long-term survival of chronic heart failure patients found out the dependence on the overall index of the Physical Health Component Living Quality Questionnaire SF-36. The overall score of the Questionnaire SF-36 ≤ 34.5 is the survival predicting factor for patients with chronic heart failure of III functional class NYHA during the 2nd and 3rd years of observation irrespectively of the value of left ventricular ejection fraction, usage of angiotensin-converting enzyme inhibitors and beta-blockers, and gender distribution. The above-mentioned predicting factor of the Questionnaire SF-36 less than 34.5 is the most comprehensive in predicting fatal end during the 2nd year of patient supervision period (relative risk value being within 1.56).