Until recently we had no agents with antianginal effect due to reduction of the endothelial dysfunction. The new scheme of stable angina treatment including L-arginine has been developed . We’ve studied clinical, electrocardiographic and vascular effects of L-arginine in two forms: solution for infusion and peroral application in 27 patients with stable angina ІІ–ІІІ functional classes, in addition to the basic therapy. After exercise test the patients received solution of arginine hydrochloride 4,2% 100 ml throughout 11–12 days. Simultaneously peroral L-arginine was prescribed 10 ml twice daily (4 g of arginine). Endothelium-dependent vasodilation improved by 50.9%. Time before development of ECG signs of an ischemia and/or the beginning of the angina increased from 7,52±0.63 to 9.68±0.74 minutes, the total executed work from 339.5±48.2 W to 518.5±50.8 W (P.0.05). The quantity of the daily angina attacks has decreased from 3.14±0.45 to 1.5±0.32 (P.0.05), the quantity of night angina attacks – from 2.32±0.18 to 0.12±0.05 (P.0.01). In conclusion, addition of L-arginine to the traditional therapy improved endothelium function and increased exercise tolerance of patients with stable angina.