Іn 141 patients (age from 22 to 75 years) with chronic heart failure (CHF) II–IV functional classes NYHA we studied survival in relation to basic levels of N-terminal pro B-type natriuretic peptide (NT-proBNP) and changes of its levels over a period of in-patient treatment. Cumulative survival in patients with CHF II–IV NYHA classes during 6–12 months depended on NT-proBNP. Significantly worse survival was registered in patients with basic NT-proBNP > 1419 pg/ml (sensitivity 56–58 %, specificity 60–61 %, positive predictive accuracy 89–92 %). Cumulative survival in patients with CHF III–IV NYHA classes after therapy depended on decrease of NT-proBNP over a period of in-patient treatment. Survival was significantly worse in patients without favorable changes of NT-proBNP (either increase or decrease by less than 10 % compared to basic levels): sensitivity 68.5–71.0 %, specificity 66.6–67.0 %, positive predictive accuracy 82–90 %).