In 104 patients from 22 to 75 years with chronic heart failure (CHF) changes of Nterminal pro Btype natriuretic peptide (deltaNTproBNP) levels were studied in relation to basic clinical, hemodynamical variables and their evolution over inpatient treatment period. Reduction of NTproBNP levels over inpatient treatment period didn’t depend on etiology of CHF, gender, NYHA status and left ventricular ejection fraction (LVEF). Reduction of NTproBNP levels was significantly higher in patients with atrial fibrillation, heart rate > 100 beats/min, decrease of heart rate > 25 beats/min, levels of pulmonary hypertension 60–70 mm Hg, in age > 65 years, rating scale of clinic status (RSCS) > 10 by total score, decrease RSCS > 4 by total score, which received furosemide 80–120 mg daily over a period of inpatient treatment. Level of NTproBNP reduction directly correlated with RSCS, heart rate, deltaRSCS, delta heart rate. In group of patients with reduction of NTproBNP levels over inpatient treatment period we established significantly higher LVEF and low levels of pulmonary artery systolic pressure as compared to patients without NTproBNP reduction over inpatient treatment period.