V.M. Kovalenko, I.I. Andrushko, T.V. Talayeva Relationship of hyperhomocysteinemia with metabolic risk factors in patients with ischemic heart disease

The aim of the study was to investigate the contents of homocysteine and prevalence of hyperhomocysteinemia (HHC) in patients with ischemic heart disease (IHD) and practically healthy people and their relation to other risk factors. We included 448 patients with ischemic heart diseases, among them 304 (68 %) males and 144 (32 %) females, age from 35 to 75 years (average 56.8±0.38 years). In 265 (59 %) patients essential hypertension (EH) was diagnosed. The control group consisted of 102 practically healthy people. Plasma levels of homocysteine, lipid spectrum, C-reactive protein and interleukin-6 were studied. High normal HC level was found in 10 % healthy subjects, hyperhomocysteinemia (HHC) – in 9 %. In patients with IHD normal HC level was found only in 18 %, high normal homocysteine level – in 29 %, HHC – in 53 %. HHC was found in 65 % patients with IHD and concomitant EH. HHC in patients with IHD was associated with disorders of lipid metabolism, activation of subclinical inflammation and microproteinuria. However, plasma HC is an independent risk factor

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